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 Zambia HIV National Guidelines
 


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 Guide Editors
 Editor In Chief
    Joel E. Gallant, MD, MPH

Pharmacology Editor
    Paul Pham, PharmD, BCPS

Zambia Guideline Team
   Peter Mwaba MMed PhD FRCP
   Alywn Mwinga MMed
   Isaac Zulu MMed MPH
   Velepie Mtonga MMed
   Albert Mwango MBChB
   Jabbin Mulwanda MMed FCS
 

 

 

Drugs>Antimicrobial Agents>
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Mebendazole

Paul A. Pham Pharm.D. and John G. Bartlett M.D. 
10-19-2010

Zambia Specific Information

  • Available formulation in Zambia: Tablet (chewable): 100 mg; 500 mg.
  • Well-tolerated oral agent with comparable anthelminthic properties compared to albendazole, but appears to be more effective against whipworm (Trichuris trichiura).

REFERENCES

Zambia Information Author: Paul A. Pham, Pharm. D.

INDICATIONS

FDA

  • Enterobiasis (pinworm),
  • Hookworm
  • Ascariasis (roundworm)
  • Trichuriasis (whipworm)
NON-FDA APPROVED USES

  • Echinococcus (second line)

FORMS

brand 
name
 
generic 
Mfg 
brand 
forms
 
cost* 
VermoxMebendazoleVarious generic manufacturers PO
chew tab
100mg
$5.83

*Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP). AWP Prices were obtained and gathered by Lakshmi Vasist Pharm D using the Red Book, manufacturer's information, and the McKesson database.

^Dosage is indicated in mg unless otherwise noted.

USUAL ADULT DOSING

 

  • Roundworm (ascaris):100-200 mg PO twice daily x 5 d or 500mg PO x 1.
  • Hookworm: 100mg PO twice daily x 3 days or 500mg PO x 1.
  • Pinworm: 100mg PO x 1 (may be repeated if infection persists for 3 weeks).
  • Echinococcus: 40-50 mg/kg/d in 3 divided doses

RENAL DOSING

DOSING FOR GLOMERULAR FILTRATION OF 50-80

Usual dose.

DOSING FOR GLOMERULAR FILTRATION OF 10-50

Usual dose.

DOSING FOR GLOMERULAR FILTRATION OF <10 ML/MIN

Usual dose.

DOSING IN HEMODIALYSIS

Drug concentration not affected by dialysis; use usual dose.

DOSING IN PERITONEAL DIALYSIS

No data.

DOSING IN HEMOFILTRATION

No data.

ADVERSE DRUG REACTIONS

OCCASIONAL

  • Diarrhea
  • Abdominal pain
RARE

  • Leukopenia
  • Agranulocytosis
  • Hepatitis

DRUG INTERACTIONS

Carbamazepine: may decrease mebendazole serum levels. Consider valproic acid with co-administration.

SPECTRUM

 , Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm)

PHARMACOLOGY

Pharmacology

COMMENTS

Well-tolerated oral agent with broad-spectrum antihelmintic. Mean cure rates are >95% for pinworm, roundworm, and hookworm infections, and 35-68% for whipworm infection.

REFERENCES

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