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Paul A. Pham Pharm.D. and John G. Bartlett M.D.
06-29-2010
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Available formulation in Zambia: Tablet: 400 mg
- Due to poor bioavailability, use is limited to treatment of UTIs.
- Uncomplicated UTI: 400 mg q12h x 3 d.
- Complicated UTI: 400 mg q12h x 7 to 10 days. Treatment may need to be extended from 21 days to 12 weeks in chronic relapsing urinary tract infections.
Zambia Information Author: Paul A. Pham, Pharm. D.
- Uncomplicated endocervical and urethral gonorrhea
- Prostatitis due to E. coli
- Uncomplicated urinary tract infections (including cystitis) due to Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa , Staphylococcus epidermidis , Staphylococcus saprophyticus, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Proteus vulgaris, Staphylococcus aureus, or Streptococcus agalactiae.
- Complicated urinary tract infections due to Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, or Serratia marcescens.
- Spontaneous bacterial peritonitis prophylaxis
- Antibiotic prophylaxis in afebrile neutropenic patients with hematological malignancies
brand
name
| generic
| Mfg
| brand
forms
| cost*
|
| Noroxin | Norfloxacin | Merck | PO
tab
400mg | $4.27 |
*Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP).
AWP Prices were obtained and gathered by Lakshmi Vasist Pharm D using the Red Book, manufacturer's
information, and the McKesson database.
^Dosage is indicated in mg unless otherwise noted.
- UTI : 400mg PO twice daily.
- Uncomplicated GC : 800mg x1.
- SBP prophylaxis: 400mg PO once daily.
- Prostatitis: 400mg PO twice daily.
- Prophylaxis in neutropenic patients: 400mg PO twice daily.
Usual dose.
400 mg q12h-q24h.
400 mg once daily.
not removed in hemodialysis, dose 400 mg once daily.
400 mg once daily.
No data. Consider 400 mg q12h-24h.
- GI intolerance: diarrhea, dyspepsia and flatulence
- CNS: headache, malaise, insomnia, restlessness, dizziness
- Photosensitivity
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C. difficile colitis
- Increased LFTs
- QTc prolongation
- Seizure
- Tendon rupture (increased incidence especially seen in older patients over age 60, concurrent use of corticosteroids, kidney, heart, and lung transplant recipients)
- Antiarrhythmics (with QT prolongation: avoid concurrent use with other drugs that prolong the QT interval including class Ia or class III antiarrhythmic agents, in pts with hypokalemia, significant bradycardia, or cardiomyopathy.
- Divalent or trivalent cations (i.e., antacids, sucralfate, buffered ddI, vitamins, and minerals): interferes with norfloxacin absorption. Do not co-administer or administer norfloxacin 2 hrs before cation.
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Nitrofurantoin : may be antagonistic, avoid concurrent administration.
- Warfarin: may increase INR with co-administration. Monitor closely.
- Oral fluoroquinolone that is not well absorbed compared to most agents in this class. Main uses are as prophylaxis for spontaneous bacterial peritonitis (SBP) and prophylaxis of fever in neutropenic patients.
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