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Pham P and Bartlett JG
06-10-2008
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Available formulation in Zambia: Praziquantel Tablet: 150 mg; 600 mg.
- Second line treatment of tapeworm (T. saginata and T. solium): albendazole preferred, but if pregnant, use praziquantel 10-20mg/kg x 1.
- Bilharzia (S. haematobium and S. masoni): praziquantel 40mg/kg x 1.
Zambia Information Author: Paul A. Pham, Pharm. D.
- Schistosomiasis
- Clonorchiasis
- Opisthorchiasis
- Cysticercosis (Taenia solium)
- Cestodiasis (Tapeworm)
- Beef Tapeworm (Taenia saginata)
brand
name
| generic
| Mfg
| brand
forms
| cost*
|
| Biltricide | Praziquantel | Bayer | PO
tab
600mg | $11.91 |
*Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP).
AWP Prices were obtained and gathered by Lakshmi Vasist Pharm D using the Red Book, manufacturer's
information, and the McKesson database.
^Dosage is indicated in mg unless otherwise noted.
- Schistosomiasis: 60 milligrams/kilogram/day PO in 3 divided doses as a 1-day treatment.
- Clonorchiasis and opisthorchiasis: 75 mg/kg in 3 divided doses (must be administer at 5 hour intervals).
- Cestodiasis (Tapeworm): 10mg/kg PO x 1 dose (usual adult dose 600 mg x1).
Usual dose.
Usual dose.
Usual dose.
Not removed in hemodialysis, use usual dose.
No data.
No data.
- Malaise
- Bitter taste
- Headache
- Dizziness
- Sedation
- GI intolerance
- Abdominal pain
- Fever
- Sweating
- Fatigue
- Pruritis and rash
- Macrolides: may increase praziquantel serum concentrations.
- Phenytoin: praziquantel AUC was reduced by 70%. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
- Rifamycin: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
- Azole antifungals: may increase praziquantel serum concentrations.
- HIV protease inhibitors: may increase praziquantel serum concentrations.
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Nevirapine: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
-
Efavirenz: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
- Corticosteroids: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
- Phenobarbital: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
- Carbamazepine: may significantly decrease praziquantel serum concentration. Use with caution and monitor for clinical failure. Increase dose based on clinical response.
Very broad activity that includes S. mansoni, S. haematobium, S. japonicum, intestinal cestodes (e.g., Diphyllobothrium latum, Taenia spp., Hymenolepis, and Dipylidium caninum)
Well-tolerated agent, active against many trematodes and cestodes. Albendazole more effective for neurocystcersosis. Potential for many drug-drug interactions.
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